• optimized for semi-volatile compounds
  
  
• particulary suitable for UHPLC and SFC
  
  
• the most linear aerosoldetector
  
  
• highest sensitivity – down to the low nanogram range 
  (on column) 
  
  
• large dynamic range: 3-5 powers of ten
  
  
• excellent reproducibility, usually ≤ 3% RSD
  
  
• active pump system – for removal of excess solvent
  
  
• simple handling 
  
  
• controllable by Chemstation and EZ-Chrom software
  
  
• easy servicing – low maintenance expenditure
  
  
• elegant, robust design – space saving
  
  

NQAD™ technology comprises 3 phases:
Aerosol formation, evaporation and nucleation via water vapour condensation

Aerosolformation:
The mobile phase with the analytes is continuously vaporised; this aerosol contains particles of various sizes. The distribution of these particles can be illustrated by a Gaussian curve.


                  


Evaporation:
The mobile phase is evaporated, leaving dry particles. These particles comprise evaporation residue of the mobile phase and the sample particles themselves. The evaporation residue particles are smaller than the sample particles and are generally too small to produce condensation.

Water vapour condensation and particle count:
In the WCPC unit (water condensation particle counter) water vapour is condensed onto the larger sample particles, which serve as nucleation cores. The very much larger particles thus formed are counted electronically. The distribution of these is represented by a Gaussian curve, in other words as peaks. See also the CPC efficiency curve.

For example, for use in:

    *  impurity and active substance analyses
    *  excipient characterization
    *  cleaning validation
    *  MS method development

For compounds such as:

    *  Lipide
    *  Proteins
    *  Steroids
    *  Polymers
    *  Sugars
    *  Peptides