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Electrochemical Systems ROXY

ROXY electrochemical system


Coupling Electrochemistry with Mass Spectrometry

A simulation tool of natural redox-processes

This Potentiostat allows the simple coupling of an
electrochemical reactor with a mass spectrometer. 

The substances to be analysed are pumped through the electrochemical cell and oxidised or reduced. The resulting products are directly analysed on a mass spectrometer. The ROXY EC/LC-System is an HPLC System in combination with an electrochemical reactor. 

Thus both the separation of substances and electrochemical conversion takes place. The resulting substances are detected by coupling this system with a mass spectrometer. 

Arrange a date with us for a demonstration and experience the efficiency of the 
EC-MS system ROXY

Performance characteristics

  • oxidation/reduction/activation of different compounds

  • direct coupling to a mass spectrometer 

  • significant increase of the MS signal

  • rapid metabolite screening (phase I and phase II)

  • simulation of the effect of oxidative stress on biomolecules

  • simulation of natural redox processes

  • electrochemical cleavage of proteins/peptides

  • reduction of disulfide bridges

  • no matrix effects

  • with user-friendly, intuitive, easy-to-learn software

  • wide potential range of ± 4.9 V

  • saves time and costs compared to conventional methods 

Reactor Cells

Diagram of an lectrochemical cell

                                                            Diagram of an electrochemical cell
                                                            Please click image to enlarge

Substances are oxidized or reduced on the surface of a working electrode in the reactor cell.

The efficiency of the reaction is influenced by the analyte and by the material of the working electrode. You can choose between five different materials: glassy carbon, gold, platinum and diamond (Magic Diamond™), as well as a specially developed electrode for reduction. The particularly robust diamond electrode allows oxidation/reduction with a high voltage of ± 3.5 V, making the analysis of inert substances possible.

The special geometry of the reactor cell prevents sample adsorption and thus the risk of substance loss and carry-over. The amperometric principle of the cell also enables intermediate products to reach the mass spectrometer for analysis.

The µ-PrepCell™ is available for the generation of reaction products in µg quantities, e.g. for NMR analysis.

Öffnet einen internen Link im aktuellen FensterFlyer µ-PrepCell
Öffnet einen internen Link im aktuellen FensterFlyer SynthesisCell  
Öffnet einen internen Link im aktuellen FensterFlyer ReactorCell 
Öffnet einen internen Link im aktuellen FensterFlyer ChipCell 

List of all cells and spare parts with part no:
Öffnet einen internen Link im aktuellen FensterROXY - Reactor Cells and Spare Parts

Range of uses

Applications for EC/MS coupling
Applications for EC/MS coupling

The possibilities offered by the Roxy™-System are being continuously extended. The use of EC/MS-coupling is consequently no longer restricted to pharmaceutical applications but has advanced to include fields of research such as waste-water management, food additives, proteomics and xenobiotics.
 Working electrodes made of conductive diamond (Magic Diamond™) only produce oxygen at very high voltage levels, so that with the introduction of this electrode material the usable potential range has been extended. This also makes difficult reactions with high oxidation potential possible.
 The table shows the reactions that can currently be performed:

Metabolic reactions that can be simulated with EC/MS 

Reactions with peptides / proteins that can be performed with EC/MS 

Aliphatic hydroxylation

Reduction of disulfide bridges

Benzylic hydroxylation

Peptide cleaving C-terminal of tyrosine

Dealkylation of amines

Peptide cleaving C-terminal of tryptophan

Dealkylisation of ethers

Oxidative surface mapping

Aromatic hydroxylation




Alcohol oxidation



Specs System


Operating modes:

DC, scan, pulse

Potential range:

-4,9 V to +4,9 V

Number of controllable cells:

2 or 4 (optional)


complete reactor control via PC and control software Dialogue


from 7°C through ambient temperature to 45°C

Dimensions (b x h x d):

22 x 44 x 44 cm 


14,6 kg without column and cells


Installable syringes:



0,5 µl - 10 ml 

Flow rates:

0,0014 µl/h – 7,909 ml/min



Potentiostat and syringe pump


timed events


current flow in the cell

External output:

launches MS software

Specs Cells



ca. 175 nl


Platinum working (WE), reference (REF) and counter electrode

Channel size (WE):

25 mm x 500 µm x 5 µm (LxWxH)  

Channel size (CE):

25 mm x 500 µm x 5 µm (LxWxH)  

Wetted materials:

PEEK, fused silica, borosilicate glass, Platin 

Flow rates:

0,5 - 2,5 µl/min

Max. pressure:

50 bar



0,7 µl - 1,4 µl depending on the number of spacers

Working electrode:

platinum, gold, glassy carbon, diamond, reduction electrode

Wetted materials:

PCTFE, FEP, PEEK, working electrode

Flow rates:

5 - 20 µl/min

Max. pressure:

2,8 bar



11 µl

Working electrode:

glassy carbon, diamond, reduction electrode

Wetted materials:

PCTFE, PEEK, titanium, viton, palladium, working electrode

Flow rates:

20 - 50 µl/min

Max. pressure:

25 bar (GC electrode), 50 bar (MD electrode)


Here you can find some interesting publications concerning our electrochemical system ROXY:

Öffnet einen internen Link im aktuellen FensterROXY - Publications


Managing Director:
Joachim Paschlau

HRB 135721 München
WEEE-Reg.Nr. DE 66898529


Gesellschaft für den Vertrieb wissenschaftlicher Geräte
Otto-Hahn-Strasse 28-30
85521 Riemerling
Tel: +49 89 66055696
Fax: +49 89 60824826